Action of Glucose-I-Phosphate on the Deposition of Phosphate in the Bones of Growing Diabetic Rats

IT has been shown in a previous paper 1 that the ossification process of growing diabetic rats is strongly retarded in comparison with normal animals and that the administration of insulin restores the ossification process to a normal rate. An even more pronounced effect was obtained by daily injections of 1–2 gm./kgm. of glucose-1-phosphate over a period of 10–15 days. The ready response to glucose-1-phosphate suggested that the impairment of ossification in diabetes might be attributed to a possible glucose-1-phosphate deficiency and that this ester might act as phosphate carrier or donor in phosphate deposition in the bones.