Cobalt as a Carcinogen
THE effects of various metals on living cells in tissue culture are being investigated in this Laboratory, and a non-lethal disturbance of normal mitosis produced in chick fibroblasts by cobalt (as chloride) has already been reported 1 . This effect, which is characterized by the persistence of the...
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| Veröffentlicht in: | Nature 1954-05, Vol.173 (4409), p.822-823 |
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| creator | HEATH, J. C. |
| description | THE effects of various metals on living cells in tissue culture are being investigated in this Laboratory, and a non-lethal disturbance of normal mitosis produced in chick fibroblasts by cobalt (as chloride) has already been reported
1
. This effect, which is characterized by the persistence of the nucleoli in mitotic cells throughout prophase into meta-, ana- and telo-phase, appears to be specific for cobalt, inasmuch as no comparable effect is produced by nickel, iron, zinc, chromium, manganese or beryllium in sublethal concentrations. |
| doi_str_mv | 10.1038/173822a0 |
| format | Article |
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1
. This effect, which is characterized by the persistence of the nucleoli in mitotic cells throughout prophase into meta-, ana- and telo-phase, appears to be specific for cobalt, inasmuch as no comparable effect is produced by nickel, iron, zinc, chromium, manganese or beryllium in sublethal concentrations.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/173822a0</identifier><identifier>PMID: 13165654</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>BIOLOGY AND MEDICINE ; BIRDS ; CANCER ; CARCINOGENESIS ; Carcinogens ; Cobalt - pharmacology ; COBALT CHLORIDES ; Humanities and Social Sciences ; Humans ; letter ; MITOSIS ; multidisciplinary ; MUSCLES ; RADIATION INJURIES ; RATS ; Science ; Science (multidisciplinary) ; SOLUTIONS</subject><ispartof>Nature, 1954-05, Vol.173 (4409), p.822-823</ispartof><rights>Springer Nature Limited 1954</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-e6c35fd3ad9077fe855c14178d251d3beddb56c0259cf73df73327f2f516487f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/173822a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/173822a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13165654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4366882$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>HEATH, J. C.</creatorcontrib><creatorcontrib>Strangeways Research Lab., Cambridge, England</creatorcontrib><title>Cobalt as a Carcinogen</title><title>Nature</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>THE effects of various metals on living cells in tissue culture are being investigated in this Laboratory, and a non-lethal disturbance of normal mitosis produced in chick fibroblasts by cobalt (as chloride) has already been reported
1
. This effect, which is characterized by the persistence of the nucleoli in mitotic cells throughout prophase into meta-, ana- and telo-phase, appears to be specific for cobalt, inasmuch as no comparable effect is produced by nickel, iron, zinc, chromium, manganese or beryllium in sublethal concentrations.</description><subject>BIOLOGY AND MEDICINE</subject><subject>BIRDS</subject><subject>CANCER</subject><subject>CARCINOGENESIS</subject><subject>Carcinogens</subject><subject>Cobalt - pharmacology</subject><subject>COBALT CHLORIDES</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>MITOSIS</subject><subject>multidisciplinary</subject><subject>MUSCLES</subject><subject>RADIATION INJURIES</subject><subject>RATS</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>SOLUTIONS</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1954</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplzztLA0EQwPFFFHNGwcpSgpUWp7PvTRkOXxCw0XrZ20e8kNyG3Uvht3flIhYWwxTzY-CP0CWGewxUPWBJFSEGjlCFmRQ1E0oeowqAqBoUFRN0lvMaADiW7BRNMMWCC84qdNXE1myGmckzM2tMsl0fV74_RyfBbLK_OOwp-nh6fG9e6uXb82uzWNaWMhhqLyzlwVHj5iBl8IpzixmWyhGOHW29cy0XFgif2yCpK0OJDCRwLJiSgU7Rzfg35qHT2XaDt5829r23g2ZUCKVIQbcjsinmnHzQu9RtTfrSGPRPv_7tL_R6pLt9u_XuDx6CC7gbQS6nfuWTXsd96kvj_2ffa-he9w</recordid><startdate>19540501</startdate><enddate>19540501</enddate><creator>HEATH, J. C.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19540501</creationdate><title>Cobalt as a Carcinogen</title><author>HEATH, J. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-e6c35fd3ad9077fe855c14178d251d3beddb56c0259cf73df73327f2f516487f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1954</creationdate><topic>BIOLOGY AND MEDICINE</topic><topic>BIRDS</topic><topic>CANCER</topic><topic>CARCINOGENESIS</topic><topic>Carcinogens</topic><topic>Cobalt - pharmacology</topic><topic>COBALT CHLORIDES</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>MITOSIS</topic><topic>multidisciplinary</topic><topic>MUSCLES</topic><topic>RADIATION INJURIES</topic><topic>RATS</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>SOLUTIONS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HEATH, J. C.</creatorcontrib><creatorcontrib>Strangeways Research Lab., Cambridge, England</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Nature</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HEATH, J. C.</au><aucorp>Strangeways Research Lab., Cambridge, England</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cobalt as a Carcinogen</atitle><jtitle>Nature</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1954-05-01</date><risdate>1954</risdate><volume>173</volume><issue>4409</issue><spage>822</spage><epage>823</epage><pages>822-823</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>THE effects of various metals on living cells in tissue culture are being investigated in this Laboratory, and a non-lethal disturbance of normal mitosis produced in chick fibroblasts by cobalt (as chloride) has already been reported
1
. This effect, which is characterized by the persistence of the nucleoli in mitotic cells throughout prophase into meta-, ana- and telo-phase, appears to be specific for cobalt, inasmuch as no comparable effect is produced by nickel, iron, zinc, chromium, manganese or beryllium in sublethal concentrations.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>13165654</pmid><doi>10.1038/173822a0</doi><tpages>2</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals |
| subjects | BIOLOGY AND MEDICINE BIRDS CANCER CARCINOGENESIS Carcinogens Cobalt - pharmacology COBALT CHLORIDES Humanities and Social Sciences Humans letter MITOSIS multidisciplinary MUSCLES RADIATION INJURIES RATS Science Science (multidisciplinary) SOLUTIONS |
| title | Cobalt as a Carcinogen |
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