Salicyates and Carbohydrate Metabolism

A NUMBER of workers 1 have reported that the administration of salicylates prevents diabetic glycos-uria in man, and Ingle 2 has shown that aspirin reduces the glycosuria of rats made mildly diabetic by reason of partial pancreatectomy. We have confirmed this latter effect using rats made severely diabetic with alloxan and found that the closely related gentisic acid (2 : 5-dihydroxybenzoic acid) caused no alteration of the glycosuria, whereas cortisone exacerbated it (see diagram).