Base-Strengthening Effect of Resonant Amino Groups in some Heterocyclic Bases

Base-Strengthening Effect of Resonant Amino Groups in some Heterocyclic Bases

IT was shown by Albert and Goldacre1 that an amino group substituted in a 'resonant position' of a six-membered aromatic heterocyclic base results in a compound of enhanced basic strength. This is attributed to the replacement of a dipolar resonant form by a more stable homopolar resonant...

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Veröffentlicht in:Nature (London) 1949-04, Vol.163 (4148), p.690-691
Hauptverfasser: GORE, PETER H, PHILLIPS, JOHN N
Format: Artikel
Sprache:eng
Schlagworte:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Zusammenfassung:IT was shown by Albert and Goldacre1 that an amino group substituted in a 'resonant position' of a six-membered aromatic heterocyclic base results in a compound of enhanced basic strength. This is attributed to the replacement of a dipolar resonant form by a more stable homopolar resonant form.
ISSN:0028-0836
1476-4687
DOI:10.1038/163690a0