Utilization of Groundnut-Cake Hydrolysate as Medium for Production of Streptomycin

SINCE the announcement of the discovery of streptomycin1 rapid progress has been made in the treatment of infectious diseases which are resistant to penicillin2-9. The studies of Schatz et al.2, on the influence of the composition of the media on the production of the active agent by A. griseus, revealed that the formation of streptomycin requires the presence of a certain organic substance supplied by meat extract or corn steep liquor. The formation of streptomycin was not affected by the nature of the peptone used, though the addition of glucose increased the yield of the antibiotic. Recently, Le Page and Elizabeth Campbell10 have found that yeast extract media fortified with minerals gives the most satisfactory production of the antibiotic with A. griseus.