Amino-quinazolines

IN a journal which has recently reached us, Dewar 1 reports the preparation of the 2-amino- and 4-amino-quinazolines. In the course of work on the amino-benzadiazines and their sulphanyl derivatives carried out in these laboratories, we had also prepared the amino-quinazolines, but in some respects our results differ from those described by Dewar. Thus we obtained good yields of 2-amino-quinazoline from guanidine nitrate and O-amino-benzaldehyde, a method stated by Dewar to yield only traces of the desired product. The 4-amino-quinazoline we prepared by amination of the corresponding chloro-compound.