Sodium and Water Metabolism in Relation to Disturbances of Carbohydrate Metabolism after Adrenalectomy

WE have found that in the absence of the adrenal cortex, flavin is not transformed to flavin phosphoric acid, but that adrenalectomized animals can be kept alive with large quantities of the latter substance (vitamin B 2 ) 1 . We have also shown that lack of adrenal cortex causes serious disturbances in intermediate metabolism of carbohydrates and fats, particularly in the absorption of these substances 2–5 . In the following experiments, we have tried to show how these facts are related to the well-known disturbances of water and sodium metabolism which may cause death in adrenalectomized animals.