Scale-Up of an Intermolecular Barbier Reaction

Scale-Up of an Intermolecular Barbier Reaction

Addition of n-BuLi to a mixture of ketone (2) and 1,4-diiodobenzene provides access to alcohol (1) in high yield. This procedure has successfully been used on molar scale.

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Veröffentlicht in:Organic process research & development 1998-09, Vol.2 (5), p.287-289
Hauptverfasser: Ennis, David S, Lathbury, David C, Wanders, Andre, Watts, David
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Sprache:eng
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container_issue 5
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container_title Organic process research & development
container_volume 2
creator Ennis, David S
Lathbury, David C
Wanders, Andre
Watts, David
description Addition of n-BuLi to a mixture of ketone (2) and 1,4-diiodobenzene provides access to alcohol (1) in high yield. This procedure has successfully been used on molar scale.
doi_str_mv 10.1021/op980003k
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title Scale-Up of an Intermolecular Barbier Reaction
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