Penicillin Acylase in the Industrial Production of β-Lactam Antibiotics

Penicillin Acylase in the Industrial Production of β-Lactam Antibiotics

Immobilized penicillin acylase is a biocatalyst suitable for the kinetically controlled industrial synthesis of semi-synthetic antibiotics in aqueous environments. Amoxicillin and ampicillin are obtained by condensing 6-aminopenicillanic acid with the amide or ester of d-(−)-4-hydroxyphenylglycine a...

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Veröffentlicht in:Organic process research & development 1998-03, Vol.2 (2), p.128-133
Hauptverfasser: Bruggink, Alle, Roos, Eric C, de Vroom, Erik
Format: Artikel
Sprache:eng
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Zusammenfassung:Immobilized penicillin acylase is a biocatalyst suitable for the kinetically controlled industrial synthesis of semi-synthetic antibiotics in aqueous environments. Amoxicillin and ampicillin are obtained by condensing 6-aminopenicillanic acid with the amide or ester of d-(−)-4-hydroxyphenylglycine and d-(−)-phenylglycine, respectively. Similarly, the cephalosporin antibiotics cefadroxil and cephalexin can be obtained from 7-aminodesacetoxycephalosporanic acid.
ISSN:1083-6160
1520-586X
DOI:10.1021/op9700643