Synthesis and Process Optimization of Amtolmetin: An Antiinflammatory Agent

Synthesis and Process Optimization of Amtolmetin: An Antiinflammatory Agent

Efforts toward the synthesis and process optimization of amtolmetin guacil 1 are described. High-yielding electrophilic substitution followed by Wolf−Kishner reduction are the key features in the novel synthesis of tolmetin 2 which is an advanced intermediate of 1.

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Veröffentlicht in:Organic process research & development 2010-03, Vol.14 (2), p.362-368
Hauptverfasser: Reddy, Lekkala Amarnath, Chakraborty, Saurya, Swapna, Rodda, Bhalerao, Dinesh, Malakondaiah, Golla China, Ravikumar, Mylavarapu, Kumar, Abhijeet, Reddy, Gade Srinivas, Naram, Jyothirmayi, Dwivedi, Namrata, Roy, Arnab, Himabindu, Vurimidi, Babu, Bangaru, Bhattacharya, Apurba, Bandichhor, Rakeshwar
Format: Artikel
Sprache:eng
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Zusammenfassung:Efforts toward the synthesis and process optimization of amtolmetin guacil 1 are described. High-yielding electrophilic substitution followed by Wolf−Kishner reduction are the key features in the novel synthesis of tolmetin 2 which is an advanced intermediate of 1.
ISSN:1083-6160
1520-586X
DOI:10.1021/op900284w