Synthesis of 2-Methyl-2,5-diazabicyclo[2.2.1]heptane, Side Chain to Danofloxacin

Various syntheses of the side chain of the quinolone antibiotic danofloxacin are described. The realization that the N-methyl substitution on the side chain 2-methyl-2,5-diazabicyclo[2.2.1]heptane can reside on either nitrogen, due to the symmetry of the molecule, played a major role in the design o...

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Veröffentlicht in:	Organic process research & development 2009-03, Vol.13 (2), p.336-340
1. Verfasser:	Braish, Tamim F
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Sprache:	eng
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creator	Braish, Tamim F
description	Various syntheses of the side chain of the quinolone antibiotic danofloxacin are described. The realization that the N-methyl substitution on the side chain 2-methyl-2,5-diazabicyclo[2.2.1]heptane can reside on either nitrogen, due to the symmetry of the molecule, played a major role in the design of the commercial synthetic route.
doi_str_mv	10.1021/op8002618
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title	Synthesis of 2-Methyl-2,5-diazabicyclo[2.2.1]heptane, Side Chain to Danofloxacin
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