Synthesis of 2-Methyl-2,5-diazabicyclo[2.2.1]heptane, Side Chain to Danofloxacin
Various syntheses of the side chain of the quinolone antibiotic danofloxacin are described. The realization that the N-methyl substitution on the side chain 2-methyl-2,5-diazabicyclo[2.2.1]heptane can reside on either nitrogen, due to the symmetry of the molecule, played a major role in the design o...
Gespeichert in:
| Veröffentlicht in: | Organic process research & development 2009-03, Vol.13 (2), p.336-340 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | Various syntheses of the side chain of the quinolone antibiotic danofloxacin are described. The realization that the N-methyl substitution on the side chain 2-methyl-2,5-diazabicyclo[2.2.1]heptane can reside on either nitrogen, due to the symmetry of the molecule, played a major role in the design of the commercial synthetic route. |
|---|---|
| ISSN: | 1083-6160 1520-586X |
| DOI: | 10.1021/op8002618 |