An Improved Process for the Synthesis and Isolation of (S)-N-(1-Phenylethyl)hydroxylamine

A three-step, single-solvent telescoped process amenable to the large-scale manufacture of (S)-N-(1-phenylethyl)hydroxylamine p-toluenesulfonic acid salt is reported. This synthetic protocol has been applied to the preparation of other chiral hydroxylamines.

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Veröffentlicht in:	Organic process research & development 2009-01, Vol.13 (1), p.49-53
Hauptverfasser:	Patel, Ian, Smith, Neil A, Tyler, Simon N. G
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Sprache:	eng
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description	A three-step, single-solvent telescoped process amenable to the large-scale manufacture of (S)-N-(1-phenylethyl)hydroxylamine p-toluenesulfonic acid salt is reported. This synthetic protocol has been applied to the preparation of other chiral hydroxylamines.
doi_str_mv	10.1021/op800230f
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title	An Improved Process for the Synthesis and Isolation of (S)-N-(1-Phenylethyl)hydroxylamine
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