An Improved Process for the Synthesis and Isolation of (S)-N-(1-Phenylethyl)hydroxylamine

An Improved Process for the Synthesis and Isolation of (S)-N-(1-Phenylethyl)hydroxylamine

A three-step, single-solvent telescoped process amenable to the large-scale manufacture of (S)-N-(1-phenylethyl)hydroxylamine p-toluenesulfonic acid salt is reported. This synthetic protocol has been applied to the preparation of other chiral hydroxylamines.

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Veröffentlicht in:Organic process research & development 2009-01, Vol.13 (1), p.49-53
Hauptverfasser: Patel, Ian, Smith, Neil A, Tyler, Simon N. G
Format: Artikel
Sprache:eng
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Zusammenfassung:A three-step, single-solvent telescoped process amenable to the large-scale manufacture of (S)-N-(1-phenylethyl)hydroxylamine p-toluenesulfonic acid salt is reported. This synthetic protocol has been applied to the preparation of other chiral hydroxylamines.
ISSN:1083-6160
1520-586X
DOI:10.1021/op800230f