Practical Syntheses of Oxindole Derivatives: Chemical Development towards 2-(5-Chloro-2-oxo-2,3-dihydroindol-1-yl)acetamide and (S)-2-(5-Chloro-2-oxo-2,3-dihydroindol-1-yl)propionamide

Practical Syntheses of Oxindole Derivatives: Chemical Development towards 2-(5-Chloro-2-oxo-2,3-dihydroindol-1-yl)acetamide and (S)-2-(5-Chloro-2-oxo-2,3-dihydroindol-1-yl)propionamide

We describe development of scalable syntheses of novel oxindole-type SV2A ligands with improved potency towards seizure suppression.

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Veröffentlicht in:Organic process research & development 2009-05, Vol.13 (3), p.442-449
Hauptverfasser: Broeders, Fabienne, Defrère, Laurent, Deltent, Marie-France, Driessens, Frank, Gilson, Frédéric, Grooters, Luc, Ikonomakos, Xavier, Limauge, Frédéric, Sergeef, Emmanuel, Verstraeten, Natacha
Format: Artikel
Sprache:eng
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Zusammenfassung:We describe development of scalable syntheses of novel oxindole-type SV2A ligands with improved potency towards seizure suppression.
ISSN:1083-6160
1520-586X
DOI:10.1021/op800203p