Chemical Development of NBI-75043. Use of a Flow Reactor to Circumvent a Batch-Limited Metal−Halogen Exchange Reaction

Chemical Development of NBI-75043. Use of a Flow Reactor to Circumvent a Batch-Limited Metal−Halogen Exchange Reaction

The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.

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Veröffentlicht in:Organic process research & development 2008-09, Vol.12 (5), p.929-939
Hauptverfasser: Gross, Timothy D, Chou, Shine, Bonneville, Daniel, Gross, Raymond S, Wang, Peng, Campopiano, Onorato, Ouellette, Michael A, Zook, Scott E, Reddy, Jayachandra P, Moree, Wilna J, Jovic, Florence, Chopade, Shubham
Format: Artikel
Sprache:eng
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Zusammenfassung:The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.
ISSN:1083-6160
1520-586X
DOI:10.1021/op800071m