Kinetics and Process Development for Deoxofluorination of a Steroid

Kinetics and Process Development for Deoxofluorination of a Steroid

In this paper investigations for developing a continuous process for the fluorination of a steroid derivative with bis(methoxyethyl)-aminosulfurtrifluoride are presented. A kinetic model is suggested for this reaction. A simulation-based experimental design approach was implemented to find the optim...

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Veröffentlicht in:Organic process research & development 2008-03, Vol.12 (2), p.345-348
Hauptverfasser: Negi, Devender S, Köppling, Lars, Lovis, Kai, Abdallah, Radwan, Geisler, Jens, Budde, Uwe
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container_end_page 348
container_issue 2
container_start_page 345
container_title Organic process research & development
container_volume 12
creator Negi, Devender S
Köppling, Lars
Lovis, Kai
Abdallah, Radwan
Geisler, Jens
Budde, Uwe
description In this paper investigations for developing a continuous process for the fluorination of a steroid derivative with bis(methoxyethyl)-aminosulfurtrifluoride are presented. A kinetic model is suggested for this reaction. A simulation-based experimental design approach was implemented to find the optimum conditions for the flow reaction in a microreactor system.
doi_str_mv 10.1021/op7001485
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title Kinetics and Process Development for Deoxofluorination of a Steroid
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