Kinetics and Process Development for Deoxofluorination of a Steroid

Kinetics and Process Development for Deoxofluorination of a Steroid

In this paper investigations for developing a continuous process for the fluorination of a steroid derivative with bis(methoxyethyl)-aminosulfurtrifluoride are presented. A kinetic model is suggested for this reaction. A simulation-based experimental design approach was implemented to find the optim...

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Veröffentlicht in:Organic process research & development 2008-03, Vol.12 (2), p.345-348
Hauptverfasser: Negi, Devender S, Köppling, Lars, Lovis, Kai, Abdallah, Radwan, Geisler, Jens, Budde, Uwe
Format: Artikel
Sprache:eng
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Zusammenfassung:In this paper investigations for developing a continuous process for the fluorination of a steroid derivative with bis(methoxyethyl)-aminosulfurtrifluoride are presented. A kinetic model is suggested for this reaction. A simulation-based experimental design approach was implemented to find the optimum conditions for the flow reaction in a microreactor system.
ISSN:1083-6160
1520-586X
DOI:10.1021/op7001485