Exploiting the Differential Reactivities of Halogen Atoms: Development of a Scalable Route to IKK2 Inhibitor AZD3264

Exploiting the Differential Reactivities of Halogen Atoms: Development of a Scalable Route to IKK2 Inhibitor AZD3264

An efficient and scalable synthesis of AZD3264 is described in which the differential reactivities of various halogen atoms have been employed. The process involves five linear chemical steps with three isolated stages starting from commercially available fragments.

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Veröffentlicht in:Organic process research & development 2014-05, Vol.18 (5), p.646-651
Hauptverfasser: Murugan, Andiappan, Bachu, Sreekanth, Manjunatha, Sulur G, Ramakrishnan, Ravi, Kadambar, Vasantha Krishna, Reddy, Chandrasekhara, Torlikonda, Venkata Rao, George, Sajan, Ramasubramanian, Sridharan, Nambiar, Sudhir
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient and scalable synthesis of AZD3264 is described in which the differential reactivities of various halogen atoms have been employed. The process involves five linear chemical steps with three isolated stages starting from commercially available fragments.
ISSN:1083-6160
1520-586X
DOI:10.1021/op500105n