The Large-Scale Synthesis of (S)‑N‑Boc-bis(4-fluorophenyl)alanine
The synthesis of (S)-N-Boc-bis(4-fluorophenyl)alanine, an intermediate in the synthesis of denagliptin, is described from the synthesis of a 12 g proof of principle sample to a >900 kg cGMP manufacturing campaign. The chiral centre was established by the asymmetric hydrogenation of the sterically...
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Veröffentlicht in: | Organic process research & development 2013-01, Vol.17 (1), p.69-76 |
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Hauptverfasser: | , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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