The Large-Scale Synthesis of (S)‑N‑Boc-bis(4-fluorophenyl)alanine

The synthesis of (S)-N-Boc-bis(4-fluorophenyl)alanine, an intermediate in the synthesis of denagliptin, is described from the synthesis of a 12 g proof of principle sample to a >900 kg cGMP manufacturing campaign. The chiral centre was established by the asymmetric hydrogenation of the sterically...

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Veröffentlicht in:Organic process research & development 2013-01, Vol.17 (1), p.69-76
Hauptverfasser: Appell, Robert B, Boulton, Lee T, Daugs, Edward D, Hansen, Matt, Hanson, Christopher H, Heinrich, Jerry, Kronig, Christel, Lloyd, Richard C, Louks, David, Nitz, Mark, Praquin, Céline, Ramsden, James A, Samuel, Helen, Smit, Mark, Willets, Matthew
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Sprache:eng
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