Corey–Itsuno Reduction of Ketones: A Development of Safe and Inexpensive Process for Synthesis of Some API Intermediates

A safe and inexpensive procedure for asymmetric reduction of ketones using in situ prepared N,N-diethylaniline borane (DEANB) and oxazaborolidine catalyst from sodium borohydride, N,N-diethylaniline hydrochloride and (S)-α,α-diphenylprolinol is described. This protocol is demonstrated successfully t...

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Veröffentlicht in:	Organic process research & development 2012-04, Vol.16 (4), p.710-713
Hauptverfasser:	Mahale, Rajendra D, Chaskar, Sudhir P, Patil, Kiran E, Maikap, Golak C, Gurjar, Mukund K
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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