Corey–Itsuno Reduction of Ketones: A Development of Safe and Inexpensive Process for Synthesis of Some API Intermediates

Corey–Itsuno Reduction of Ketones: A Development of Safe and Inexpensive Process for Synthesis of Some API Intermediates

A safe and inexpensive procedure for asymmetric reduction of ketones using in situ prepared N,N-diethylaniline borane (DEANB) and oxazaborolidine catalyst from sodium borohydride, N,N-diethylaniline hydrochloride and (S)-α,α-diphenylprolinol is described. This protocol is demonstrated successfully t...

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Veröffentlicht in:Organic process research & development 2012-04, Vol.16 (4), p.710-713
Hauptverfasser: Mahale, Rajendra D, Chaskar, Sudhir P, Patil, Kiran E, Maikap, Golak C, Gurjar, Mukund K
Format: Artikel
Sprache:eng
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Zusammenfassung:A safe and inexpensive procedure for asymmetric reduction of ketones using in situ prepared N,N-diethylaniline borane (DEANB) and oxazaborolidine catalyst from sodium borohydride, N,N-diethylaniline hydrochloride and (S)-α,α-diphenylprolinol is described. This protocol is demonstrated successfully to manufacture enantiopure dapoxetine at the plant scale.
ISSN:1083-6160
1520-586X
DOI:10.1021/op300034u