Improved Process for Ranolazine: An Antianginal Agent
An improved process has been developed for the active pharmaceutical ingredient, ranolazine with 99.9% purity and 47% overall yield (including three chemical reactions and one recrystallization). Formation and control of all the possible impurities is described. All the solvents used in the process...
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Veröffentlicht in: | Organic process research & development 2012-05, Vol.16 (5), p.748-754 |
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container_title | Organic process research & development |
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creator | Aalla, Sampath Gilla, Goverdhan Anumula, Raghupathi Reddy Kurella, Srinivas Padi, Pratap Reddy Vummenthala, Prabhakar Reddy |
description | An improved process has been developed for the active pharmaceutical ingredient, ranolazine with 99.9% purity and 47% overall yield (including three chemical reactions and one recrystallization). Formation and control of all the possible impurities is described. All the solvents used in the process were recovered and reused. The unreacted piperazine is recovered as piperazine monophosphate monohydrate salt. |
doi_str_mv | 10.1021/op300026r |
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Formation and control of all the possible impurities is described. All the solvents used in the process were recovered and reused. The unreacted piperazine is recovered as piperazine monophosphate monohydrate salt.</description><identifier>ISSN: 1083-6160</identifier><identifier>EISSN: 1520-586X</identifier><identifier>DOI: 10.1021/op300026r</identifier><language>eng</language><publisher>American Chemical Society</publisher><ispartof>Organic process research & development, 2012-05, Vol.16 (5), p.748-754</ispartof><rights>Copyright © 2012 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a259t-3d7287ab8fe194b6f5ede41dbda76a450e151acaee657be6a1aba41ed5e1a25e3</citedby><cites>FETCH-LOGICAL-a259t-3d7287ab8fe194b6f5ede41dbda76a450e151acaee657be6a1aba41ed5e1a25e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/op300026r$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/op300026r$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids></links><search><creatorcontrib>Aalla, Sampath</creatorcontrib><creatorcontrib>Gilla, Goverdhan</creatorcontrib><creatorcontrib>Anumula, Raghupathi Reddy</creatorcontrib><creatorcontrib>Kurella, Srinivas</creatorcontrib><creatorcontrib>Padi, Pratap Reddy</creatorcontrib><creatorcontrib>Vummenthala, Prabhakar Reddy</creatorcontrib><title>Improved Process for Ranolazine: An Antianginal Agent</title><title>Organic process research & development</title><addtitle>Org. 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Process Res. Dev</addtitle><date>2012-05-18</date><risdate>2012</risdate><volume>16</volume><issue>5</issue><spage>748</spage><epage>754</epage><pages>748-754</pages><issn>1083-6160</issn><eissn>1520-586X</eissn><abstract>An improved process has been developed for the active pharmaceutical ingredient, ranolazine with 99.9% purity and 47% overall yield (including three chemical reactions and one recrystallization). Formation and control of all the possible impurities is described. All the solvents used in the process were recovered and reused. The unreacted piperazine is recovered as piperazine monophosphate monohydrate salt.</abstract><pub>American Chemical Society</pub><doi>10.1021/op300026r</doi><tpages>7</tpages></addata></record> |
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title | Improved Process for Ranolazine: An Antianginal Agent |
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