Improved Process for Ranolazine: An Antianginal Agent

An improved process has been developed for the active pharmaceutical ingredient, ranolazine with 99.9% purity and 47% overall yield (including three chemical reactions and one recrystallization). Formation and control of all the possible impurities is described. All the solvents used in the process...

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Veröffentlicht in:Organic process research & development 2012-05, Vol.16 (5), p.748-754
Hauptverfasser: Aalla, Sampath, Gilla, Goverdhan, Anumula, Raghupathi Reddy, Kurella, Srinivas, Padi, Pratap Reddy, Vummenthala, Prabhakar Reddy
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container_end_page 754
container_issue 5
container_start_page 748
container_title Organic process research & development
container_volume 16
creator Aalla, Sampath
Gilla, Goverdhan
Anumula, Raghupathi Reddy
Kurella, Srinivas
Padi, Pratap Reddy
Vummenthala, Prabhakar Reddy
description An improved process has been developed for the active pharmaceutical ingredient, ranolazine with 99.9% purity and 47% overall yield (including three chemical reactions and one recrystallization). Formation and control of all the possible impurities is described. All the solvents used in the process were recovered and reused. The unreacted piperazine is recovered as piperazine monophosphate monohydrate salt.
doi_str_mv 10.1021/op300026r
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title Improved Process for Ranolazine: An Antianginal Agent
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