Improved Process for Ranolazine: An Antianginal Agent

Improved Process for Ranolazine: An Antianginal Agent

An improved process has been developed for the active pharmaceutical ingredient, ranolazine with 99.9% purity and 47% overall yield (including three chemical reactions and one recrystallization). Formation and control of all the possible impurities is described. All the solvents used in the process...

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Veröffentlicht in:Organic process research & development 2012-05, Vol.16 (5), p.748-754
Hauptverfasser: Aalla, Sampath, Gilla, Goverdhan, Anumula, Raghupathi Reddy, Kurella, Srinivas, Padi, Pratap Reddy, Vummenthala, Prabhakar Reddy
Format: Artikel
Sprache:eng
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Zusammenfassung:An improved process has been developed for the active pharmaceutical ingredient, ranolazine with 99.9% purity and 47% overall yield (including three chemical reactions and one recrystallization). Formation and control of all the possible impurities is described. All the solvents used in the process were recovered and reused. The unreacted piperazine is recovered as piperazine monophosphate monohydrate salt.
ISSN:1083-6160
1520-586X
DOI:10.1021/op300026r