Scalable Synthesis of Cyclotriphenolene

Scalable Synthesis of Cyclotriphenolene

Hyperpolarized xenon magnetic resonance imaging (129Xe MRI) is becoming a powerful imaging method that requires cage molecules to encapsulate xenon. Cyclotriphenolene 1 is a key compound for the synthesis of cryptophane cages. A scalable procedure for the synthesis of cyclotriphenolene 1 was develop...

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Veröffentlicht in:Organic process research & development 2011-03, Vol.15 (2), p.435-437
Hauptverfasser: Traoré, Ténin, Delacour, Léa, Kotera, Naoko, Merer, Goulven, Buisson, David-Alexandre, Dupont, Christophe, Rousseau, Bernard
Format: Artikel
Sprache:eng
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Zusammenfassung:Hyperpolarized xenon magnetic resonance imaging (129Xe MRI) is becoming a powerful imaging method that requires cage molecules to encapsulate xenon. Cyclotriphenolene 1 is a key compound for the synthesis of cryptophane cages. A scalable procedure for the synthesis of cyclotriphenolene 1 was developed by which 40 g of 1 can now be synthesized within 3 days, starting from inexpensive benzyl alcohol.
ISSN:1083-6160
1520-586X
DOI:10.1021/op100260w