Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102

Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102

A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process incorporates a new asymmetric synthesis of (R)-tert-butylaminoindan, which is based on a chiral auxiliary induced diastereoselective reduction of it...

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Veröffentlicht in:Organic process research & development 2007-05, Vol.11 (3), p.578-584
Hauptverfasser: Lukin, Kirill, Hsu, Margaret C, Chambournier, Gilles, Kotecki, Brian, Venkatramani, C. J, Leanna, M. Robert
Format: Artikel
Sprache:eng
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Zusammenfassung:A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process incorporates a new asymmetric synthesis of (R)-tert-butylaminoindan, which is based on a chiral auxiliary induced diastereoselective reduction of its iminoindan precursor.
ISSN:1083-6160
1520-586X
DOI:10.1021/op060228s