Development of a Practical High-Yield Industrial Synthesis of Pergolide Mesylate

Development of a Practical High-Yield Industrial Synthesis of Pergolide Mesylate

The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying] affords pergolide mesylate 1 in 75−81% overall yie...

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Veröffentlicht in:Organic process research & development 2006-03, Vol.10 (2), p.198-202
Hauptverfasser: Cabri, Walter, Roletto, Jacopo, Olmo, Sara, Fonte, Piera, Ghetti, Paolo, Songia, Simonetta, Mapelli, Elio, Alpegiani, Marco, Paissoni, Paolo
Format: Artikel
Sprache:eng
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Zusammenfassung:The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying] affords pergolide mesylate 1 in 75−81% overall yield from dihydrolysergic acid 4 with >99.8% purity.
ISSN:1083-6160
1520-586X
DOI:10.1021/op0501747