Preparation of Optically Pure Esomeprazole and Its Related Salt

Preparation of Optically Pure Esomeprazole and Its Related Salt

The magnesium salt of (S)-isomer of omeprazole, with a trade name of Nexium, is the first proton-pump inhibitor developed as a single isomer for the treatment of acid-related diseases. A process for the preparation of the optically pure (S)-isomer of omeprazole through transition metal complex is de...

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Veröffentlicht in:Organic process research & development 2006-01, Vol.10 (1), p.33-35
Hauptverfasser: Raju, Satya V. N, Purandhar, Koilkonda, Reddy, Padi Pratap, Reddy, Ghanta Mahesh, Reddy, Lekkala Amarnath, Reddy, Kikkuri Srirami, Sreenath, Keshaboina, Mukkanti, Kagga, Reddy, Ganji Santhi
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Sprache:eng
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Zusammenfassung:The magnesium salt of (S)-isomer of omeprazole, with a trade name of Nexium, is the first proton-pump inhibitor developed as a single isomer for the treatment of acid-related diseases. A process for the preparation of the optically pure (S)-isomer of omeprazole through transition metal complex is described.
ISSN:1083-6160
1520-586X
DOI:10.1021/op049779d