An Improved Large Scale Synthesis of the Schöllkopf Chiral Auxiliaries:  (2R)- and (2S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

An Improved Large Scale Synthesis of the Schöllkopf Chiral Auxiliaries:  (2R)- and (2S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

Syntheses of the Schöllkopf chiral auxiliaries have been carried out on large scale in high overall yields from d- and l-valine. This method avoids the use of highly toxic phosgene or triphosgene, low-temperature reactions, and unstable intermediates.

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Veröffentlicht in:Organic process research & development 2005-03, Vol.9 (2), p.185-187
Hauptverfasser: Chen, Jianxie, Corbin, Scott P, Holman, Nicholas J
Format: Artikel
Sprache:eng
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Zusammenfassung:Syntheses of the Schöllkopf chiral auxiliaries have been carried out on large scale in high overall yields from d- and l-valine. This method avoids the use of highly toxic phosgene or triphosgene, low-temperature reactions, and unstable intermediates.
ISSN:1083-6160
1520-586X
DOI:10.1021/op049777t