A Practical Synthesis of the Platelet Fibrinogen Antagonist, Elarofiban

A Practical Synthesis of the Platelet Fibrinogen Antagonist, Elarofiban

Elarofiban is a novel, nonpeptide, orally active fibrinogen receptor antagonist useful for the treatment of platelet mediated thrombotic disorders (Costanzo, M. J.; Hoekstra, W. J.; Maryanoff, B. E. WO, 97/41102, 1997). Herein we describe the process research that was carried out for the synthesis o...

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Veröffentlicht in:Organic process research & development 2003-11, Vol.7 (6), p.866-872
Hauptverfasser: Cohen, Judith H, Bos, Mary Ellen, Cesco-Cancian, Sergio, Harris, Bruce D, Hortenstine, John T, Justus, Michael, Maryanoff, Cynthia A, Mills, John, Muller, Stefan, Roessler, Armin, Scott, Lorraine, Sorgi, Kirk L, Villani, Frank J, Webster, Robin R. H, Weh, Christian
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Sprache:eng
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Zusammenfassung:Elarofiban is a novel, nonpeptide, orally active fibrinogen receptor antagonist useful for the treatment of platelet mediated thrombotic disorders (Costanzo, M. J.; Hoekstra, W. J.; Maryanoff, B. E. WO, 97/41102, 1997). Herein we describe the process research that was carried out for the synthesis of elarofiban that eventually led to the development of a safe and cost-effective commercial scale process.
ISSN:1083-6160
1520-586X
DOI:10.1021/op034103o