Rapid Improvement of a Reductive Sulfonylation Using Design of Experiment Methods

Rapid Improvement of a Reductive Sulfonylation Using Design of Experiment Methods

Sulfone 2 was initially prepared using a zinc-mediated one-pot coupling procedure. A traditional sodium sulfite-mediated two-pot procedure was found to eliminate a major impurity, yet modest yields prevailed. Design of experiment methods with the aid of a basic parallel synthesizer rapidly led to a...

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Veröffentlicht in:Organic process research & development 2003-05, Vol.7 (3), p.313-317
Hauptverfasser: Chen, Jiong Jack, Nugent, Thomas C, Lu, Cuong V, Kondapally, Sudharani, Giannousis, Peter, Wang, Ying, Wilmot, Jeremy T
Format: Artikel
Sprache:eng
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Zusammenfassung:Sulfone 2 was initially prepared using a zinc-mediated one-pot coupling procedure. A traditional sodium sulfite-mediated two-pot procedure was found to eliminate a major impurity, yet modest yields prevailed. Design of experiment methods with the aid of a basic parallel synthesizer rapidly led to a high-yielding one-pot process.
ISSN:1083-6160
1520-586X
DOI:10.1021/op034018g