Streamlining Process R&D Using Multidimensional Analytical Technology

The combination of multidimensional analytical technology to form a single nth-order analyzer can produce reaction process data more efficiently and may provide data that are inaccessible using conventional techniques. A 3rd-order analyzer was assembled utilizing a Mettler RC1 calorimeter, Applied systems, Inc. ReactIR and Hewlett-Packard 5971A mass selective detector. The 3rd-order analyzer was utilized to simultaneously perform reaction calorimetry, in situ infrared spectroscopy, and in situ mass spectrometry on the conversion of a vinyl sulfone to a vinyl tributylstannane. The goal of complete material and energy balance, coupled with knowledge of scale-up issues, was achieved in a single experiment and in real time.