Research and Development of a Second-Generation Process for Bosentan, an Endothelin Receptor Antagonist

A second-generation manufacturing process from 5-(2-methoxyphenoxy)-[2,2‘-bipyrimidine]-4,6-(1H,5H)-dione to bosentan is based on the synthesis and deprotection of the tert-butyl ether of bosentan using available and inexpensive ethylene glycol mono-tert-butyl ether. This new strategy triggered a ca...

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Veröffentlicht in:	Organic process research & development 2002-03, Vol.6 (2), p.120-124
Hauptverfasser:	Harrington, Peter J, Khatri, Hiralal N, DeHoff, Brad S, Guinn, Martin R, Boehler, Mark A, Glaser, Karl A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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