Process Development and Preparation of 2-Deoxyparaherquamide:  Implementation of a Selective Reduction of Secondary Amides on a Kilogram Scale

Process Development and Preparation of 2-Deoxyparaherquamide:  Implementation of a Selective Reduction of Secondary Amides on a Kilogram Scale

The preparation of 2-deoxyparaherquamide, PNU-141962, is accomplished through the indirect selective reduction of a secondary amide in the presence of a tertiary amide. The kilogram-scale process is safe and robust and allows for the isolation of analytically pure material in high overall yield with...

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Veröffentlicht in:Organic process research & development 2002-03, Vol.6 (2), p.192-196
Hauptverfasser: Mauragis, Michael A, Lipton, Michael F, Veley, Michael F
Format: Artikel
Sprache:eng
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Zusammenfassung:The preparation of 2-deoxyparaherquamide, PNU-141962, is accomplished through the indirect selective reduction of a secondary amide in the presence of a tertiary amide. The kilogram-scale process is safe and robust and allows for the isolation of analytically pure material in high overall yield without a chromatographic purification.
ISSN:1083-6160
1520-586X
DOI:10.1021/op010233q