A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC
Enantiomerically pure cetirizine can be prepared by preparative HPLC separation of cetirizine amide. The amide has an α value of 2.76 (USP resolution of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run.
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| Veröffentlicht in: | Organic process research & development 2001-03, Vol.5 (2), p.110-115 |
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| container_end_page | 115 |
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| container_issue | 2 |
| container_start_page | 110 |
| container_title | Organic process research & development |
| container_volume | 5 |
| creator | Pflum, Derek A Wilkinson, H. Scott Tanoury, Gerald J Kessler, Donald W Kraus, Hali B Senanayake, Chris H Wald, Stephen A |
| description | Enantiomerically pure cetirizine can be prepared by preparative HPLC separation of cetirizine amide. The amide has an α value of 2.76 (USP resolution of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run. |
| doi_str_mv | 10.1021/op0002951 |
| format | Article |
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| ispartof | Organic process research & development, 2001-03, Vol.5 (2), p.110-115 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1021_op0002951 |
| source | ACS Publications |
| title | A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC |
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