A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC

A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC

Enantiomerically pure cetirizine can be prepared by preparative HPLC separation of cetirizine amide. The amide has an α value of 2.76 (USP resolution of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic process research & development 2001-03, Vol.5 (2), p.110-115
Hauptverfasser: Pflum, Derek A, Wilkinson, H. Scott, Tanoury, Gerald J, Kessler, Donald W, Kraus, Hali B, Senanayake, Chris H, Wald, Stephen A
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Enantiomerically pure cetirizine can be prepared by preparative HPLC separation of cetirizine amide. The amide has an α value of 2.76 (USP resolution of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run.
ISSN:1083-6160
1520-586X
DOI:10.1021/op0002951