Facile Preparation of 3-(1-Piperazinyl)-1H-indazoles

Facile Preparation of 3-(1-Piperazinyl)-1H-indazoles

Pre-clinical evaluation of a potential antipsychotic agent required a convenient synthesis of 3-(1-piperazinyl)-1H-indazole derivatives. Improvements of the original preparation provided a five-step sequence to an unsubstituted piperazine intermediate, with a 67% overall yield. All intermediates wer...

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Veröffentlicht in:Organic process research & development 2001-03, Vol.5 (2), p.179-183
Hauptverfasser: Leroy, Vincent, Lee, George E, Lin, Jiang, Herman, Sandra H, Lee, Thomas B
Format: Artikel
Sprache:eng
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Zusammenfassung:Pre-clinical evaluation of a potential antipsychotic agent required a convenient synthesis of 3-(1-piperazinyl)-1H-indazole derivatives. Improvements of the original preparation provided a five-step sequence to an unsubstituted piperazine intermediate, with a 67% overall yield. All intermediates were isolated by filtration.
ISSN:1083-6160
1520-586X
DOI:10.1021/op0002242