Epicalyxin F and Calyxin I:  Two Novel Antiproliferative Diarylheptanoids from the Seeds of Alpinia b lepharocalyx

Epicalyxin F and Calyxin I:  Two Novel Antiproliferative Diarylheptanoids from the Seeds of Alpinia b lepharocalyx

Epicalyxin F (1) and calyxin I (2), two novel diarylheptanoids, were isolated from a residual fraction of an EtOH extract of Alpinia blepharocalyx. Calyxin I (2) represented a new carbon skeleton, and epicalyxin F (1) possessed potent antiproliferative activity toward HT-1080 fibrosarcoma and colon...

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Veröffentlicht in:Organic letters 1999-12, Vol.1 (11), p.1733-1736
Hauptverfasser: Gewali, Mohan B, Tezuka, Yasuhiro, Banskota, Arjun H, Ali, Mohammad Shawkat, Saiki, Ikuo, Dong, Hui, Kadota, Shigetoshi
Format: Artikel
Sprache:eng
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Zusammenfassung:Epicalyxin F (1) and calyxin I (2), two novel diarylheptanoids, were isolated from a residual fraction of an EtOH extract of Alpinia blepharocalyx. Calyxin I (2) represented a new carbon skeleton, and epicalyxin F (1) possessed potent antiproliferative activity toward HT-1080 fibrosarcoma and colon 26-L5 carcinoma with ED50 values of 1.71 and 0.89 μM, respectively.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol990260p