Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones

Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones

The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (

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Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2009-01, Vol.11 (2), p.265-268
Hauptverfasser: Rubio-Pérez, Laura, Pérez-Flores, F. Javier, Sharma, Pankaj, Velasco, Luis, Cabrera, Armando
Format: Artikel
Sprache:eng
Schlagworte:
Air
Amination
Aniline Compounds - chemistry
Catalysis
Crystallography, X-Ray
Hydrogen - chemistry
Ketones - chemistry
Oxidation-Reduction
Palladium - chemistry
Stereoisomerism
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Zusammenfassung:The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (
ISSN:1523-7060
1523-7052
DOI:10.1021/ol802336m