Four-Component Benzyne Coupling Reactions: A Concise Total Synthesis of Dehydroaltenuene B

Four-Component Benzyne Coupling Reactions: A Concise Total Synthesis of Dehydroaltenuene B

A four-component coupling reaction of 3,5-dimethoxybenzyne with 2-methyl-2-cyclohexenylmagnesium chloride, carbon dioxide, and iodine was utilized as a key step in the first total synthesis of dehydroaltenuene B.

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Veröffentlicht in:Organic letters 2008-09, Vol.10 (17), p.3833-3835
Hauptverfasser: Soorukram, Darunee, Qu, Tao, Barrett, Anthony G. M
Format: Artikel
Sprache:eng
Schlagworte:
Ascomycota - chemistry
Benzene Derivatives - chemistry
Cyclohexenes - chemistry
Lactones - chemical synthesis
Magnesium - chemistry
Mycotoxins - chemical synthesis
Organometallic Compounds - chemistry
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Zusammenfassung:A four-component coupling reaction of 3,5-dimethoxybenzyne with 2-methyl-2-cyclohexenylmagnesium chloride, carbon dioxide, and iodine was utilized as a key step in the first total synthesis of dehydroaltenuene B.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol8015435