Responsive Two-Photon Induced Europium Emission as Fluorescent Indicator for Paralytic Shellfish Saxitoxin

A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (K B = 6.1 × 104 M–1)...

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Veröffentlicht in:	Organic letters 2011-10, Vol.13 (19), p.5036-5039
Hauptverfasser:	He, Shuzhong, Li, Hongguang, Yip, Yuk-Wang, Yeung, Chi-Tung, Fung, Yuen On, Kong, Hoi-Kuan, Yeung, Ho-Lun, Law, Ga-Lai, Wong, Ka-Leung, Lee, Chi-Sing, Lam, Michael Hon-Wah, Murphy, Margaret B, Lam, Paul Kwan-Sing, Wong, Wing-Tak
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Europium - chemistry Fluorescent Dyes - chemistry Molecular Structure Photons Saxitoxin - chemistry Shellfish
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (K B = 6.1 × 104 M–1) and triggers a two-photon induced f–f emission enhancement by over 100% and increases the two-photon absorption cross-section from 9 to 36 GM.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol2018246