Synthesis of Chiral Cyclobutane Containing C 3-Symmetric Peptide Dendrimers

Synthesis of Chiral Cyclobutane Containing C 3-Symmetric Peptide Dendrimers

Five new highly functionalized cyclobutane containing C 3-symmetric peptide dendrimers have been synthesized through a convergent approach from 1,3,5-trisubstituted benzene and chiral γ,ε-amino diacid derivatives as well as a γ-tetrapeptide. The first example of the synthesis of N-centered amides by...

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Veröffentlicht in:Organic letters 2010-07, Vol.12 (14), p.3148-3151
Hauptverfasser: Gutiérrez-Abad, Raquel, Illa, Ona, Ortuño, Rosa M
Format: Artikel
Sprache:eng
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Zusammenfassung:Five new highly functionalized cyclobutane containing C 3-symmetric peptide dendrimers have been synthesized through a convergent approach from 1,3,5-trisubstituted benzene and chiral γ,ε-amino diacid derivatives as well as a γ-tetrapeptide. The first example of the synthesis of N-centered amides by using 1,3,5-triaminobenzene and a carboxylic acid is reported.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1010664