Preparation and Diastereoselective O rtho-Metalation of Chiral Ferrocenyl Imidazolines:  Remarkable Influence of LDA as Metalation Additive

Preparation and Diastereoselective O rtho-Metalation of Chiral Ferrocenyl Imidazolines:  Remarkable Influence of LDA as Metalation Additive

The preparation of optically pure ferrocenyl imidazolines starting from ferrocenecarboxylic acid and the application to diastereoselective ortho-metalations is described highlighting the remarkable influence of lithium dialkylamides, especially LDA, as metalation additives (in combination with tert-...

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Veröffentlicht in:Organic letters 2005-09, Vol.7 (19), p.4137-4140
Hauptverfasser: Peters, René, Fischer, Daniel F
Format: Artikel
Sprache:eng
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Zusammenfassung:The preparation of optically pure ferrocenyl imidazolines starting from ferrocenecarboxylic acid and the application to diastereoselective ortho-metalations is described highlighting the remarkable influence of lithium dialkylamides, especially LDA, as metalation additives (in combination with tert-butyllithium) on the diastereoselectivity.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol051437k