Sporolides A and B:  Structurally Unprecedented Halogenated Macrolides from the Marine Actinomycete Salinispora t ropica

Sporolides A and B:  Structurally Unprecedented Halogenated Macrolides from the Marine Actinomycete Salinispora t ropica

Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscop...

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Veröffentlicht in:Organic letters 2005-06, Vol.7 (13), p.2731-2734
Hauptverfasser: Buchanan, Greg O, Williams, Philip G, Feling, Robert H, Kauffman, Christopher A, Jensen, Paul R, Fenical, William
Format: Artikel
Sprache:eng
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Zusammenfassung:Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol050901i