Asymmetric Hydrocyanation of Hydrazones Catalyzed by Lanthanide−PYBOX Complexes

Asymmetric Hydrocyanation of Hydrazones Catalyzed by Lanthanide−PYBOX Complexes

The asymmetric addition of HCN to hydrazones is catalyzed in high yield and good-to-excellent enantioselectivity by the easily prepared (PhPYBOX)ErCl3 complex. This constitutes the first example of asymmetric catalytic hydrocyanation of hydrazones.

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Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2004-01, Vol.6 (2), p.153-155
Hauptverfasser: Keith, John M, Jacobsen, Eric N
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Hydrazones - chemistry
Hydrogen Cyanide - chemistry
Lanthanoid Series Elements - chemistry
Molecular Structure
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Beschreibung
Zusammenfassung:The asymmetric addition of HCN to hydrazones is catalyzed in high yield and good-to-excellent enantioselectivity by the easily prepared (PhPYBOX)ErCl3 complex. This constitutes the first example of asymmetric catalytic hydrocyanation of hydrazones.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol035844c