An Efficient and Practical N-Methylation of Amino Acid Derivatives

An Efficient and Practical N-Methylation of Amino Acid Derivatives

An efficient and practical N-methylation of amino acid derivatives with dimethyl sulfate in the presence of sodium hydride and a catalytic amount of water is described. Reaction of water with sodium hydride generated highly reactive dry sodium hydroxide, which led to much faster reaction rates than...

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Veröffentlicht in:Organic letters 2003-01, Vol.5 (2), p.125-128
Hauptverfasser: Prashad, Mahavir, Har, Denis, Hu, Bin, Kim, Hong-Yong, Repic, Oljan, Blacklock, Thomas J
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - chemical synthesis
Methylation
Sodium Hydroxide - chemistry
Sulfuric Acid Esters - chemistry
Water - chemistry
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Zusammenfassung:An efficient and practical N-methylation of amino acid derivatives with dimethyl sulfate in the presence of sodium hydride and a catalytic amount of water is described. Reaction of water with sodium hydride generated highly reactive dry sodium hydroxide, which led to much faster reaction rates than powdered sodium hydroxide itself.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0268440