Silicon Tether-Aided Coupling Metathesis:  Application to the Synthesis of Attenol A

Silicon Tether-Aided Coupling Metathesis:  Application to the Synthesis of Attenol A

A new synthesis of attenol A is described. Key features of this work include a crucial silicon tether-aided coupling metathesis step and the use of iodoetherification as an efficient protection method for 1,5-ene-ols.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2002-11, Vol.4 (23), p.4105-4108
Hauptverfasser: Van de Weghe, Pierre, Aoun, Darina, Boiteau, Jean-Guy, Eustache, Jacques
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - toxicity
Catalysis
Cell Survival - drug effects
Ethers, Cyclic - chemical synthesis
Ethers, Cyclic - toxicity
Molecular Structure
Silicon
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A new synthesis of attenol A is described. Key features of this work include a crucial silicon tether-aided coupling metathesis step and the use of iodoetherification as an efficient protection method for 1,5-ene-ols.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0268438