Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter Targeting Potential Agents for Alzheimer's Disease

Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter Targeting Potential Agents for Alzheimer's Disease

Highly efficient acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. Both compounds showed potent inhibitory activities against AChE and SERT.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2002-10, Vol.4 (20), p.3359-3362
Hauptverfasser: Kogen, Hiroshi, Toda, Narihiro, Tago, Keiko, Marumoto, Shinji, Takami, Kazuko, Ori, Mayuko, Yamada, Naho, Koyama, Kazuo, Naruto, Shunji, Abe, Kazumi, Yamazaki, Reina, Hara, Takao, Aoyagi, Atsushi, Abe, Yasuyuki, Kaneko, Tsugio
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholinesterase - chemistry
Acetylcholinesterase - metabolism
Alzheimer Disease - drug therapy
Binding Sites
Cholinesterase Inhibitors - chemical synthesis
Cholinesterase Inhibitors - chemistry
Cholinesterase Inhibitors - metabolism
Cholinesterase Inhibitors - pharmacology
Drug Design
Humans
Inhibitory Concentration 50
Molecular Structure
Serotonin - metabolism
Serotonin Uptake Inhibitors - chemical synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Highly efficient acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. Both compounds showed potent inhibitory activities against AChE and SERT.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol026418e