Synthesis of the C1−C12 Fragment of Fostriecin

The synthesis of the C1−C12 fragment of fostriecin was achieved from (S)-glycidol in 15 steps by using an enantioselective allytitanation reaction and a ring-closure metathesis as the key steps.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2001-07, Vol.3 (14), p.2233-2235
Hauptverfasser:	Cossy, Janine, Pradaux, Fabienne, BouzBouz, Samir
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemical synthesis Alkenes - chemistry Antibiotics, Antineoplastic - chemical synthesis Antibiotics, Antineoplastic - chemistry Cyclization Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Epoxy Compounds - chemical synthesis Epoxy Compounds - chemistry Molecular Structure Polyenes Propanols - chemical synthesis Propanols - chemistry Pyrones Stereoisomerism Structure-Activity Relationship Topoisomerase II Inhibitors
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Beschreibung
Zusammenfassung:	The synthesis of the C1−C12 fragment of fostriecin was achieved from (S)-glycidol in 15 steps by using an enantioselective allytitanation reaction and a ring-closure metathesis as the key steps.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol016116x