Synthesis of the Diazonamide A Macrocyclic Core via a Dieckmann-Type Cyclization

Suzuki coupling of 18 and 30 affords 9 as an interconverting mixture of two atropisomers. Treatment with LDA at −23 °C affords the macrocyclic ketone 8 in 57% yield.

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Veröffentlicht in:	Organic letters 2001-08, Vol.3 (16), p.2451-2454
Hauptverfasser:	Vedejs, Edwin, Zajac, Matthew A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Cyclization Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - chemistry Indicators and Reagents Magnetic Resonance Spectroscopy Marine Toxins - chemical synthesis Marine Toxins - chemistry Oxazoles - chemical synthesis Oxazoles - chemistry
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Beschreibung
Zusammenfassung:	Suzuki coupling of 18 and 30 affords 9 as an interconverting mixture of two atropisomers. Treatment with LDA at −23 °C affords the macrocyclic ketone 8 in 57% yield.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol016097r